Saroj Kumar Lab
Alzheimer's Disease
Our research focuses on developing new compounds to improve Alzheimer's Disease (AD) treatment. Unlike current drugs, which only offer symptomatic relief, our novel derivatives target key pathological factors in AD, such as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition. These compounds also cross the blood-brain barrier, counteract oxidative stress, and reduce Aβ1-42 toxicity—critical contributors to AD progression. In pre-clinical models, the compounds improved cognitive function, reduced oxidative stress, and showed neuroprotective effects, offering potential as disease-modifying treatments for AD.
Parkinson’s Disease
Parkinson’s disease (PD) is a chronic progressive second most common neurodegenerative disease worldwide. Till date, no effective treatment to arrest disease progression and has huge burden on health care system. The main reason is the loss of dopaminergic neurons leading to dopamine depletion. One of the reasons for the wide variations in prevalence rates is the lack of proper diagnostic tools to detect in the early stages where they may be more effective to halt disease progression. Our aim is to extract, characterize and validate the exosomes from the patients sample and develop a non-invasive method to correlates the exosomes level with disease severity. This target to be a potential cost effective novel biomarker for diagnostic approaches.
Breast Cancer
Breast cancer is a major global health issue. It has the highest rate of incidence and is the second major cause of mortality in women. It causes extensive individual suffering and gives a huge burden on the health care in society. Despite extensive research and different tools have been developed to assist clinicians in selecting patients who should receive adjuvant therapy, it still remains a challenge. While current searches for markers involved further processing of the cancer patient samples involving costly reagents such as specific antibodies, no reagent and special sample preparation is required for FTIR imaging make this technique very economical. This technique gives information on chemical changes that started with the initiation of disease, hence help the clinician for early detection and increased the rate of survival. The long term purpose is to further develop infrared biomarker based methodology for other cancer and neurodegenerative disease.